Research of subchronic oral toxicity after the injection of organotin compounds containing a fragment of 2,6-di-tert-butylphenol

Objective : to assess the subchronic toxicity of bis(3,5-di-tert-butyl-4-hydroxyphenyl)dimethyltin (Me-3) and (3,5-di-tert-butyl-4-hydroxyphenyl)triphenyltin (Me-5) with identification external signs changes in indicators functional state liver kidneys Wistar rats (females) 14-fold daily intragastric injection simulate a metronomic chemotherapy regimen. Materials method study was conducted on 24 weighing 190-210 g. The tested compounds were administered fourteen times intragastrically at total dose 2000 mg/kg for Me-3, 954 Me-5. Results substances belonging class organic tin derivatives: features toxic process detoxification organs (liver kidneys) administration revealed. doses amounting half-year fourteen-fold did not cause death animals development toxicity, noted. Conclusion analysis results will allow us develop optimal schemes organotin containing fragment 2,6-di-tert-butylphenol